NADPH oxidase-derived reactive oxigen species enhance antigen cross-presentation of dendritic cells
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منابع مشابه
NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.
The phagocyte NADPH oxidase (NOX2) is critical for the bactericidal activity of phagocytic cells and plays a major role in innate immunity. We showed recently that NOX2 activity in mouse dendritic cells (DCs) prevents acidification of phagosomes, promoting antigen cross-presentation. In order to investigate the role of NOX2 in the regulation of the phagosomal pH in human DCs, we analyzed the pr...
متن کاملNADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells Running title: Phagosomal pH regulation in human DC
The phagocyte NADPH oxidase (NOX2) is critical for the bactericidal activity of phagocytic cells and plays a major role in innate immunity. We showed recently that NOX2 activity in mouse dendritic cells (DC) prevents acidification of phagosomes, promoting antigen crosspresentation. In order to investigate the role of NOX2 in the regulation of the phagosomal pH in human DC, we analyzed the produ...
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Dendritic cells (DCs) continuously scavenge their environment to capture invading pathogens for presentation to T cells. To increase the antigen presentation potential, DCs are equipped with several mechanisms that reduce antigen degradation. Alkalization of the endosomal and phagosomal compartments by reactive oxygen species (ROS) produced by NADPH oxidases is one of these mechanisms. In neutr...
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The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2 (.-)). This radical is an important precursor of hydrogen peroxide (H2O2) and other reactive oxygen species needed for microbicidal activity during innate immune responses. Inherited defects in NADPH oxidase give rise to chronic granulomatous di...
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Dendritic cells (DCs) present foreign antigen in major histocompatibility complex (MHC) class I molecules to cytotoxic T cells in a process called cross-presentation. An important step in this process is the release of antigen from the lumen of endosomes into the cytosol, but the mechanism of this step is still unclear. In this study, we show that reactive oxygen species (ROS) produced by the N...
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